Votre mission :

CONTEXT

DBS: from genetic mutations to motor circuit dysfunctions & recovery
DBS is an exciting new interdisciplinary, collaborative, and multi-model project at the ICM. By bridging approaches across disciplines, the project’s goal is to build novel strategies to improve dopaminergic cell survival and deep-brain stimulation of resilient circuits in Parkinson’s disease.

Collective Interest Projects - Collaborative, interdisciplinary, innovative & transformative
As part of DBS, we will implement the hiring of post-docs each dedicated to one collective interest project to be cosupervised by two ICM team leaders, experts from different fields. The early-career researchers will receive training in the field that they have not received training on yet, either genetics, cellular physiology, imaging, optogenetics, behavior or modelling. We aim to attract high level interdisciplinary researchers by offering world class research facilities and double supervision from leaders in the relevant fields. You would be part of a dynamic community of young researchers within a highly collaborative environment.

MISSIONS
- Generate neuroanatomical map of the MLR in monkey and human using 2D and 3D histological tools
(immnunostaining and in situ hybridization)
- Perform spatial transcriptomics on MLR
- Generate single cell profiling of accessible chromatin using ATACseq
- Plan experiments, collect data, and analyze results.
- Organize tasks and participate in DBS project discussions.

Votre profil :

Know-how

- Strong experience and technical skills to perform 2D and 3D histology.
- Ability to acquire high quality images using multiple microscopy equipment.
- Good autonomy within planning experimental protocols.
- Rigorous with data analysis.
- Ability to work in a project-based mode.


Knowledge

- Applicants must have a strong background in neuroanatomy. He/she must hold (or are expected to complete
soon) a PhD or equivalent degree in biology, medicine or molecular biology.
- Experience with 2D and 3D histology methods, imaging and image analysis.
- Experience with omic data analysis and chromatin profiling.
- Excellent verbal and written communication skills in English are required.


Soft skills

- Accountability and commitment to collective goals.
- Integrity, honesty, and steadfast loyalty.
- Teamwork and solidarity, actively engaged in team welfare.
- Initiative, motivation, and inquisitiveness.
- Willingness to impart knowledge and promote good scientific practices with respect for individuals.
- Scientific rigor, meticulous attention to detail, excellent organizational skills, precision, and discipline


The Paris Brain Institute is committed to combating all forms of discrimination. We guarantee an inclusive and
respectful working environment that embraces diversity.
All our positions are open to people with disabilities.


Apply on our career site with your resume and cover letter in English in a single document.
https://offres.institutducerveau-icm.org//fr/jobs/1893-91

A propos de INSTITUT DU CERVEAU :

L'Institut du Cerveau est un établissement dédié à la recherche, à la compréhension et au traitement des troubles neurologiques et des maladies du cerveau. L'Institut unit des scientifiques de diverses disciplines, notamment la neurologie, la neurochirurgie, la neuro-imagerie, la neuropsychologie et la génétique, dans le but de collaborer sur des projets de recherche novateurs.
Les objectifs incluent la découverte de nouvelles thérapies pour traiter les maladies neurologiques telles que la maladie d'Alzheimer, la maladie de Parkinson, la sclérose en plaques, les troubles du mouvement, les troubles de l'humeur et bien d'autres. Ils cherchent également à mieux comprendre le fonctionnement du cerveau humain dans des états normaux et pathologiques.