Votre mission :

Team

Alexandra Durr and Sandrine Humbert’s team focus on neurogenetic diseases, spinocerebellar degenerations (spastic paraplegias and cerebellar ataxias) and Huntington disease. These rare conditions share a late onset even though the mutant genes are expressed since conception and are critical for brain development. Our team showed that brain development is altered in Huntington disease, one of this rare inherited disease, and that these alterations contribute to the late onset. 

Application

Sending a detailed CV including a list of publications, a brief outline of current research, scientific interests and career goals, as well as the name and contact details of references to alexandra.durr[a]icm-institute.org and sandrine.humbert[a]icm-institute.org

Votre profil :

Aim: identifying the underlying mechanism of the cellular and circuits defects in the developing brain of rare neurogenetic diseases. The project is to tackle this issue through single nuclei RNA sequencing of different brain areas of the developing human and mouse brain.

 
Highly motivated and skilled person with:

- Strong background in human genetics and knowledge of functional genomics
- Proficiency in bioinformatics tools and statistics for genetic analysis (DNA and RNA)
- Coding abilities with mastery of scripting languages (Bash, Python, R) 
- Familiarity with database management and data integration
- Experience in using nextflow pipelines would be a plus


Apply on our career site with your resume and cover letter in English in a single document.
https://offres.institutducerveau-icm.org//fr/jobs/1891-76

A propos de INSTITUT DU CERVEAU :

L'Institut du Cerveau est un établissement dédié à la recherche, à la compréhension et au traitement des troubles neurologiques et des maladies du cerveau. L'Institut unit des scientifiques de diverses disciplines, notamment la neurologie, la neurochirurgie, la neuro-imagerie, la neuropsychologie et la génétique, dans le but de collaborer sur des projets de recherche novateurs.
Les objectifs incluent la découverte de nouvelles thérapies pour traiter les maladies neurologiques telles que la maladie d'Alzheimer, la maladie de Parkinson, la sclérose en plaques, les troubles du mouvement, les troubles de l'humeur et bien d'autres. Ils cherchent également à mieux comprendre le fonctionnement du cerveau humain dans des états normaux et pathologiques.